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While the specific mechanisms underlying these GSH/GSSG redox disturbances are not clear, these findings highlight the role of GSH/GSSG redox in asthma control and suggest that systemic measures of GSH and GSSG, as opposed to total glutathione alone, may be particular relevance in these subjects

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In humans, GSH levels can be assessed in the brain in vivo using magnetic resonance spectroscopy (MRS), a powerful non-invasive technique for cerebral metabolite quantification, as well as in autopsy brain tissue and peripheral blood using biochemical assays, such as high-performance liquid chromatography (HPLC) (Asensi et al., 1994)