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These systems enhance bioavailability through multiple mechanisms: particle size reduction increases surface area-to-volume ratios, amorphous state formation prevents crystallization, and surface modification improves wettability

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(7) M.Hrelec et al (2009) Abdominal aorta anastomosis in rats and stable gastric pentadecapeptide BPC 157, prophylaxis and therapy – Journal of Physiology and Pharmacology, 2009 Dec:60 Suppl 7:161-5