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2 Oxidative stress in periodontal and peri-implant diseases Oxidative stress refers to a pathological state in which the production of reactive oxygen species (ROS) exceeds the capacity of endogenous antioxidant defense systems, resulting in irreversible molecular damage and dysregulated redox signaling ( Under physiological conditions, ROS serve as essential second messengers in cellular signaling, regulating processes such as proliferation, differentiation, apoptosis, and antimicrobial defense