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Due to the antioxidant properties of melatonin, it plays an important role in neovascularization and angiogenesis via decreasing Ang-1/2, VEGF, and VEGFR expression during hypoxia

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Notably, all KLHDC10 residues identified in our structure as interacting with ubiquitin’s C-terminal sequence were previously shown by mutagenesis to impair Ala tail substrate binding in cells and by co-immunoprecipitation and pull-down studies with mutant KLHDC10 proteins 40