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To investigate whether the observed liver inflammation caused by S-amlodipine was a result of direct effects on the liver, we performed an in vitro experiment in which the reference concentration (1.25 ~ 20 μm) of S-amlodipine in the human liver and placebo (0 μm S-amlodipine) were chosen to treat HepG2 cells, and the placebo-treated cells were used as a control